Venom of the giant ant Dinoponera quadriceps attenuates inflammatory pain in mouse cutaneous wound healing model

Arthropod venoms are potential sources of bioactive substances, providing tools for the validation popular use and new drugs design. Ants belonging to genus Dinoponera used in folk medicine treat inflammatory conditions. It was previously demonstrated that venom giant ant quadriceps (DqV), containing a mixture polypeptides, elicit antinociceptive effect mice models chemical, mechanical thermal nociception. The aim this study evaluate DqV antiinflammatory antihypernociceptive effects model traumatic cutaneous wound. Colonies D. were collected ‘Serra de Maranguape’ (State Ceará, northeastern Brazil), small mountain range located on coastal zone, secreted by glands extracted with capillary tubes, further lyophilized maintained at -20 ± 1ºC until use. Wounds performed dorsum Swiss mice. Animals received intravenous (i.v.) injection (50 µg kg-1 day-1) during 3 days evaluation parameters present wounds: hypernociception, leukocyte infiltrate, myeloperoxidase activity, nitrite/nitrate content. Data tested two-way ANOVA Bonferroni’s post-hoc test. reduced (2.7 folds) hypernociception 48 hours, infiltration 65% 6 hours activity 60% 0.5 hour after wound induction. In conclusion, from attenuates inflammation wounds.